Luận văn Thạc sĩ Khoa học: Nghiên cứu các xanthanolid và các thành phần hóa học khác của cây Ké đầu ngựa (Xanhthium strumarium L., Asteraceae) mọc ở Hà Nội

  ===  === Trn Th Hin  XANTHIUM STRUMARIUM   Hà Ni  2014

  ===  === Trn Th Hin  XANTHIUM STRUMARIUM    60440114   - 2014

Lu  n v  n Tha  Khoa Hoá h  c   Tr  n Th  Hi  n   c K22 LI C Luc hoàn thành ti Phòng thí nghim Hoá hc các hp cht thiên nhiên, B môn Hoá hi hc Khoa hc T i hc Quc gia Hà Ni. Em xin chân thành c   tài, hng dn ch bo, tu kin thí nghim thun l em trong sut quá trình làm Lu  c kt qu này em xin bày t lòng bi c ti GS. TSKH. Phan T to mu kin thí nghim thun li,  em hoàn thành Lu Cui cùng em xin cy, các anh, ch em trong Phòng thí nghim Hoá hc các hp cho mng nghiên cu thun li và giúp d em trong thi gian em nghiên cu và hoàn thành Lu Hà Ni, ngày 25 tháng 03 14 Hc viên cao hc 

Lu  n v  n Tha  Khoa Hoá h  c   Tr  n Th  Hi  n   c K22   ............................................................................................................ 1 AN ..................................................................................... 3 1.1 XANTHIUM  ........... 3 Xanthium .............................................................. 3 Xanthium...  ................................................. 5 c ................................................ 5  ............................................................................................. 15  ................................................................................... 17 glycosid ....................................................................... 20  ...................................................................... 21 Xanthium strarium L.) ...................................................... 22  ................................................................................................. 22  .................................................................... 23  ............................................................................. 27  .................................................................................. 27 u ch các phn chit ................................................................................ 27  ............................... 27 nh cu trúc các hp cht ..................................................................... 28   ........................................................................................... 29  ....................................................... 30 2.3.1 Nguyên liu thc vt ..................................................................................... 30 ..0

Lu  n v  n Tha  Khoa Hoá h  c   Tr  n Th  Hi  n   c K22  ....................................... 31  ................................. 32 2.4.1 Phn chin-hexan (XSLH) ..................................................................... 32  (XSLD)................................................................. 34 n-hexan (XSCH) ................................................................ 34 XSCD) ............................................................ 36  ...................................... 37 n-hexan (XSLH) ..................................................... 37 XSLD) ................................................ 38 n-hexan (XSCH) ................................................ 39 XSCD) ........................................... 40  ................... 40  ......................................................... 46  ........................................................................................ 46  .................................................. 46   n-hexan (XSLH) .................................................... 49 XSLD) ................................................ 49  ............................................. 51 n-hexan (XSCH) ................................................ 51 XSCD) ........................................... 51  ...................................................... 53  .............................................................................................................. 63  ...................................................................................... 65

Lu  n v  n Tha  Khoa Hoá h  c   Tr  n Th  Hi  n   c K22 DANH MC CÁC CH VIT TT CC (Column Chromatography): Sc kí ci trng lc dung môi DEPT (Disstortionless Enhancement by Polarition Transfer): Ph DEPT ESI-MS (ElectroSpray Ionization-Mass Spectrometry): Ph kh     FC (Flash Chromatography): Sc kí ct nhanh Mini-C (Mini-Column Chromatography): Sc kí ct tinh ch RP-18 TLC (Thin-Layer Chromatography): Sc kí lp mng 1 H-NMR (Proton Nuclear Magnetic Resonance): Ph c ng t ht nhân proton 13 C-NMR (Carbon-13 Nuclear Magnetic Resonance): Ph cng t ht nhân carbon-13

Lu  n v  n Tha  Khoa Hoá h  c   Tr  n Th  Hi  n   c K22 DANH MC CÁC HÌNH, CÁC B Xanthium Xanthium strumarium L.)   n-hexan (XSLH) XSLD) n-hexan (XSCH) XSCD)... ... ...48 .. 

Lu  n v  n Tha  Khoa Hoá h  c   Tr  n Th  Hi  n   c K22 DANH MC CÁC PH LC Ph lc 1 Ph 1 H-NMR ca XSLH4.1 (I) Ph lc 2: Ph 13 C-NMR và DEPT ca XSLH4.1 (I) Ph lc 3: Ph ESI-MS-(+) ca XSLH4.1 (I) : Ph ESI-MS-(-) ca XSLH4.1 (I) Ph lc 5: Ph 1 H-NMR ca XSLH8.1 (III) Ph lc 6: Ph 13 C-NMR và DEPT ca XSLH8.1 (III) Ph lc 7: Ph 1 H-NMR ca XSLH8.2.5 (IV) Ph lc 8: Ph 1 H-NMR ca XSLD3.3 (V) Ph lc 9: Ph 13 C-NMR ca XSLD3.3 (V) Ph lc 10: Ph 1 H-NMR ca XSLD7.2 (VI) Ph lc 11: Ph ESI-MS ca XSLD7.2 (VI) Ph lc 12: Ph 1 H-NMR ca XSLD10.1 (VII) Ph lc 13: Ph 13 C-NMR và DEPT ca XSLD10.1 (VII)  1 H-NMR ca XSCD2.2 (VIII) Ph lc 15: Ph 1 H-NMR ca XSCD6.1 (IX) Ph lc 16: Ph 13 C-NMR và DEPT ca XSCD6.1 (IX)

Lu  n v  n Tha  Khoa Hoá h  c   1 Trâ       .    . trong Y ,  hiên      t   tro          nhiên.                              nhiên    (Xanthium strumarium L.) Xanthium           l       Theo m       cây Xanthium strumarium L.    .  n,     Xanthium

Lu  n v  n Tha  Khoa Hoá h  c   2 Trâ            thiên nhiên. C vXanthium strumarium L.  Nam. :    Xanthium strumarium        : -   cây Xanthium strumarium L.; -  ; -                     